![]() ![]() This can lead to exacerbations in asthmatic clients or in those with COPD as beta 2 blockade causes constriction of the bronchioles in the lungs. Blockers that aren’t cardio-selective may cause blockade of other beta receptors including receptors in the lungs. Adverse Effects of Beta-Blockersīeta-blockers differ on account of their selectivity for beta 1 receptors in the body. By blocking this effect, these medications lead to a reduction of heart rate (negative chronotropic) and force of contraction (negative inotropic) which leads to a decrease in resistance, workload, and cardiac output. These essentially work by acting against the sympathetic nervous system, the “fight or flight” mechanisms in your body, by preventing the ability of norepinephrine and epinephrine to increase heart rate and force of contraction during times of stress. MOAs work by blocking beta receptors in the central nervous system which slows the heart rate and contractility of the heart. Anxiety: Decreased heart rate and sympathetic (fight or flight) activity on the heart – reduces the spread of norepinephrine to the brain and body.Angina and myocardial infarction: Decreased heart rate reduces the cardiac demand in the heart preventing ischemia and serious damage to the heart tissue.Atrial fibrillation and cardiac arrhythmia: Reduces heart rate preventing the heart from beating too quickly leading to serious cardiac events (e.g.Hypertension: Decreased heart rate and force of contraction → decreased blood pressure and cardiac output. ![]() ![]() Other common indications include atrial fibrillation or general anxiety disorders where the goal is to slow the heart rate in response to stress.īeta-blockers are all named with the suffix “lol” or “olol” which helps when trying to memorize this class of medications Beta-Blocker Indications ![]() The most prescribed indication is hypertension in clients who have either tachycardia (HR > 100 bpm) or in clients with hypertension that was not reduced after initiating other blood pressure medications (e.g. ![]()
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